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December 21, 2021

HUTER ongoing research

Date: December 21st 2021

HUTER Work Package Leader Dave Monk Phd., has coordinated actions with his research team and entities as the Wellcome Sanger Institute (WSI) and Fundación para la Investigación del Hospital Clínico de la Comunidad Valenciana (INCLIVA).

The report presents the first version of the “Methylome for normal endometrial and myometrium tissues, cataloguing cell types”. Also, addresses two main areas:

a) Optimisation of the single-cell methylation methodologies.

b) Acquisition of healthy tissue biopsies.

As a result, they have successfully compared numerous protocols, which has revealed that EM-seq has not only the most streamlined protocol but the best library coverage and lowest duplication rate using an endometrial cell line.

Link to Zenodo:

About the Human Uterus Cells Atlas - HUTER

The human uterus is a flagship reproductive organ with profound implications not only in reproduction but also in women ́s health. HUTER can advance the Human Cell Atlas initiative for the exploitation potential in Obstetrics and Gynecology and biomedicine research areas such as Regenerative Medicine or Reproductive Medicine.

The uterus is itself a model for regenerative medicine since (i) endometrial tissue regenerates monthly and its transformation is executed through dynamic changes in states and interactions of multiple cell types, and (ii) myometrial tissue has remarkable regenerative capacity and extensive remodelling throughout pregnancy. Hence, the primary motivation HUTER proposal stems from the need to better understand the human uterus in order to more effectively address uterine diseases that impact women ́s health such as myomas or endometriosis and/or might contribute to infertility, infant and maternal mortality and morbidity.

HUTER technological and biological platform will be a crucial resource for the scientific and clinical communities to define the cellular basis of health and disease, allowing the rapid development of new diagnosis and prognosis tools and therapeutic advancements in the field.

Link to the project website here